Gender differences in 1-year clinical characteristics and outcomes after stroke: results from the China National Stroke Registry

PLoS One. 2013;8(2):e56459. doi: 10.1371/journal.pone.0056459. Epub 2013 Feb 13.


Background: Previous reports have shown inconsistent results on clinical outcomes between women and men after stroke, and little is known about gender differences on outcomes in Chinese post-stroke patients. The aim of this study was to explore whether there were gender differences on clinical characteristics and outcomes in Chinese patients after ischemic stroke by using the data from the China National Stroke Registry (CNSR).

Methods and findings: Out of 12,415 consecutively recruited patients with acute ischemic stroke in the CNSR from 2007 to 2008, 11,560 (93.1%) patients were followed up for 12 months. Their clinical characteristics and outcomes on death, recurrence, and dependency were recorded. The multivariate logistic regression was performed to determine whether there were gender differences in these outcomes. Women were older than men at baseline (67.9 vs. 64.0 years, P<0.001). Women had a higher mortality, recurrence rate, and dependency rate at 3, 6, and 12 months than men, but after adjusting for age, history of diabetes, pre-stroke dependency, stroke severity, in-hospital complications, and other confounders, there were no statistically significant differences in gender on mortality and recurrence rate at 3, 6, and 12 months; and dependency rate at 3, and 6 months. However, the dependency rate at 12 months remained significantly higher in women (odds ratio, 1.24; 95% confidence interval, 1.06 to 1.45).

Conclusions: There are many differences in clinical characteristics between women and men after ischemic stroke in China. Compared with men, women are more dependent at 12 months after stroke. This difference still exists after controlling the potential confounders.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Asian Continental Ancestry Group
  • China
  • Female
  • Follow-Up Studies
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Outcome Assessment, Health Care / methods
  • Outcome Assessment, Health Care / statistics & numerical data*
  • Prospective Studies
  • Recurrence
  • Registries / statistics & numerical data*
  • Sex Factors
  • Stroke / diagnosis*
  • Stroke / ethnology
  • Stroke / mortality
  • Survival Rate
  • Time Factors

Grant support

This study was funded by the Ministry of Science and Technology and the Ministry of Health of the People's Republic of China and the Grant No. is National S & T Major Project of China (2011BAI08B02) and by the Research Special Fund For Public Welfare Industry of Health (200902004). Grants were received from State Key Development, Program of Basic Research of China [2009CB521905], the National Science Foundation (grant no. 81071115), and the Beijing Science and Technology Committee (grant no. 7102050). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.