New alkaloid from Streptomyces koyangensis residing in Odontotermes formosanus

J Asian Nat Prod Res. 2013;15(4):422-5. doi: 10.1080/10286020.2013.767246. Epub 2013 Feb 18.

Abstract

A new alkaloid was isolated from the ethyl acetate extract of the culture of a termite-associated Streptomyces koyangensis BY-4. The structure of 1 was elucidated by using MS, NMR, electronic circular dichroism data, and computational approaches. Compound 1 showed weak antimicrobial activities against a panel of test microbes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Aspergillus niger / drug effects
  • Bacillus subtilis / drug effects
  • Candida albicans / drug effects
  • Circular Dichroism
  • Cryptococcus neoformans / drug effects
  • Escherichia coli / drug effects
  • Indolizines / chemistry
  • Indolizines / isolation & purification*
  • Indolizines / pharmacology
  • Isoptera / microbiology*
  • Microbial Sensitivity Tests
  • Micrococcus luteus / drug effects
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Pseudomonas aeruginosa / drug effects
  • Staphylococcus aureus / drug effects
  • Streptococcus pyogenes / drug effects
  • Streptomyces / chemistry*

Substances

  • 2-ethyl-7-hydroxy-6,7-dihydro-5H-indolizin-3-one
  • Alkaloids
  • Indolizines