The role of nutrition and diet in Alzheimer disease: a systematic review

J Am Med Dir Assoc. 2013 Jun;14(6):398-402. doi: 10.1016/j.jamda.2013.01.014. Epub 2013 Feb 16.


The role of nutrition in modulating Alzheimer disease (AD) remains uncertain. Persons ingesting a Mediterranean-type diet appear to be less likely to develop AD. Epidemiologically, food combinations rich in antioxidant vitamins reduced the risk of AD. Combination formulas (eg, Souvenaid) appear to have small effects on cognition. B-vitamin supplements were mostly disappointing with inconsistent findings, except in countries where bread is not fortified with folate. They were generally negative, as were studies investigating omega-3 fatty acid supplementation. Based on this review, a Mediterranean diet and/or a combination supplement, such as Souvenaid, appear to be the most beneficial approaches with the least possible adverse effects to slowing the progression of AD.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Alzheimer Disease / diet therapy*
  • Alzheimer Disease / prevention & control*
  • Diet, Mediterranean
  • Dietary Supplements
  • Disease Progression
  • Fatty Acids, Omega-3 / administration & dosage
  • Humans
  • Risk Assessment
  • Trace Elements / administration & dosage
  • Trace Elements / adverse effects
  • Vitamins / administration & dosage


  • Fatty Acids, Omega-3
  • Trace Elements
  • Vitamins