Abstract
A practical zinc insertion starting from cheap commercial zinc powder and TMPCl (1-chloro-2,2,6,6-tetramethylpiperidine) allows a fast and efficient synthesis of the zinc base TMPZnCl·LiCl under mild conditions in high yields. This base is kinetically highly active and was used for the regio- and chemoselective functionalization of dibromodiazines (pyridazines and pyrazines).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Combinatorial Chemistry Techniques
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Hydrocarbons, Chlorinated / chemical synthesis*
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Hydrocarbons, Chlorinated / chemistry*
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Lithium / chemistry*
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Molecular Structure
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Organometallic Compounds / chemical synthesis*
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Organometallic Compounds / chemistry
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Piperidines / chemistry*
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Pyridazines / chemical synthesis*
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Pyridazines / chemistry
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Stereoisomerism
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Zinc / chemistry*
Substances
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1-chloro-2,2,6,6-tetramethylpiperidine
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Hydrocarbons, Chlorinated
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Organometallic Compounds
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Piperidines
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Pyridazines
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Lithium
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Zinc