Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall

J Am Chem Soc. 2013 Mar 6;135(9):3311-4. doi: 10.1021/ja309036q. Epub 2013 Feb 21.


The reactions of all seven Escherichia coli lytic transglycosylases with purified bacterial sacculus are characterized in a quantitative manner. These reactions, which initiate recycling of the bacterial cell wall, exhibit significant redundancy in the activities of these enzymes along with some complementarity. These discoveries underscore the importance of the functions of these enzymes for recycling of the cell wall.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Wall / chemistry
  • Cell Wall / enzymology
  • Cell Wall / metabolism*
  • Escherichia coli / cytology
  • Escherichia coli / enzymology*
  • Escherichia coli / metabolism*
  • Escherichia coli Proteins / metabolism*
  • Glycoside Hydrolases / metabolism*
  • Molecular Conformation
  • Saccule and Utricle / chemistry
  • Saccule and Utricle / metabolism


  • Escherichia coli Proteins
  • Glycoside Hydrolases
  • slt protein, E coli