Novel microbial transformation of desacetylcinobufagin by Fusarium avenaceum AS 3.4594

J Asian Nat Prod Res. 2013;15(3):294-9. doi: 10.1080/10286020.2013.763227. Epub 2013 Feb 19.

Abstract

In this paper, the microbial transformation of desacetylcinobufagin (1) by Fusarium avenaceum AS 3.4594 was investigated, and four metabolites were isolated and characterized as 3-keton-desacetylcinobufagin (2), 3-epi-desacetylcinobufagin (3), bufadienolide A (4), and 15β,16α-dihydroxyl-17βH-bufalin (5), respectively. Among them, 4 and 5 are new compounds. The cytotoxicities of transformed products (2-5) against Hela cells were also investigated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biotransformation
  • Bufanolides / chemistry
  • Bufanolides / isolation & purification*
  • Fusarium / metabolism*
  • HeLa Cells
  • Humans
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Bufanolides
  • desacetylcinobufagin