Lipid-lowering effects of standardized extracts of Ilex paraguariensis in high-fat-diet rats

Fitoterapia. 2013 Apr;86:115-22. doi: 10.1016/j.fitote.2013.02.008. Epub 2013 Feb 17.

Abstract

Mate (Ilex paraguariensis A. St.-Hil) is a native species of South America used to prepare traditional beverages. Recently a possible effect of its infusion on oxidative stress found in dyslipidemias has been reported. The main compounds related to these activities are phenolic compounds derived from chlorogenic acid. This study aimed to determine the anticholesteremic effect of the hydroethanolic extract (HEIP) and its n-butanolic fraction (n-BFIP), with standardized content of phenolic compounds derived from chlorogenic acid, in rats treated with high-fat diet (HFD). The contents of these compounds in the ethanol extract and n-butanol fraction were respectively two and three times higher than in traditional infusion with predominance of dicaffeoylquinic derivatives. The extracts were able to reduce serum triglycerides and cholesterol and decrease the atherogenic index in treated animals. These results support a potential effect of the mate extract in cardiovascular disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atherosclerosis / prevention & control
  • Chlorogenic Acid / analogs & derivatives
  • Chlorogenic Acid / analysis
  • Chlorogenic Acid / pharmacology
  • Chlorogenic Acid / therapeutic use
  • Cholesterol / blood
  • Diet, High-Fat / adverse effects*
  • Dyslipidemias / blood
  • Dyslipidemias / drug therapy*
  • Dyslipidemias / etiology
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / drug therapy
  • Hypercholesterolemia / etiology
  • Hypolipidemic Agents / pharmacology*
  • Hypolipidemic Agents / therapeutic use
  • Ilex paraguariensis / chemistry*
  • Lipids / blood*
  • Male
  • Oxidative Stress / drug effects
  • Phenols / analysis
  • Phenols / pharmacology*
  • Phenols / therapeutic use
  • Phytotherapy
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Wistar
  • Triglycerides / blood

Substances

  • Hypolipidemic Agents
  • Lipids
  • Phenols
  • Plant Extracts
  • Triglycerides
  • Chlorogenic Acid
  • Cholesterol