Photodynamic Therapy (PDT): PDT Mechanisms

doi:10.5946/ce.2013.46.1.24

. 2013 Jan;46(1):24-9.

doi: 10.5946/ce.2013.46.1.24. Epub 2013 Jan 31.

Photodynamic Therapy (PDT): PDT Mechanisms

Ron R Allison¹, Keyvan Moghissi

Affiliations

PMID: 23422955
PMCID: PMC3572346
DOI: 10.5946/ce.2013.46.1.24

Photodynamic Therapy (PDT): PDT Mechanisms

Ron R Allison et al. Clin Endosc. 2013 Jan.

. 2013 Jan;46(1):24-9.

doi: 10.5946/ce.2013.46.1.24. Epub 2013 Jan 31.

Authors

Ron R Allison¹, Keyvan Moghissi

Affiliation

¹ 21st Century Oncology, Greenville, NC, USA.

PMID: 23422955
PMCID: PMC3572346
DOI: 10.5946/ce.2013.46.1.24

Abstract

Photodynamic therapy (PDT) is a light based therapy used to ablate tumors. As practiced in oncology a photosensitizing agent is applied and then activated by a specific wavelength and energy of light. This light energy in the presence of oxygen will lead to the creation of the photodynamic reaction which is cyto and vasculo toxic. This paper will review the mechanisms of action of PDT and how they may be manipulated to improve clinical outcome in cancer patients.

Keywords: Mechanisms; Photochemotherapy; Photodynamic reaction; Photosensitizing agents.

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Conflict of interest statement

The authors have no financial conflicts of interest.

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References

1. Dougherty TJ, Gomer CJ, Henderson BW, et al. Photodynamic therapy. J Natl Cancer Inst. 1998;90:889–905. - PMC - PubMed
1. Allison RR, Mota HC, Sibata CH. Clinical PD/PDT in North America: an historical review. Photodiagnosis Photodyn Ther. 2004;1:263–277. - PubMed
1. Lipson RL, Baldes EJ. The photodynamic properties of a particular hematoporphyrin derivative. Arch Dermatol. 1960;82:508–516. - PubMed
1. Lipson RL, Baldes EJ. Photosensitivity and heat. Arch Dermatol. 1960;82:517–520. - PubMed
1. Dougherty TJ. Photodynamic therapy (PDT) of malignant tumors. Crit Rev Oncol Hematol. 1984;2:83–116. - PubMed

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[1] Dougherty TJ, Gomer CJ, Henderson BW, et al. Photodynamic therapy. J Natl Cancer Inst. 1998;90:889–905. - PMC - PubMed

[2] Dougherty TJ, Gomer CJ, Henderson BW, et al. Photodynamic therapy. J Natl Cancer Inst. 1998;90:889–905. - PMC - PubMed

[3] Allison RR, Mota HC, Sibata CH. Clinical PD/PDT in North America: an historical review. Photodiagnosis Photodyn Ther. 2004;1:263–277. - PubMed

[4] Allison RR, Mota HC, Sibata CH. Clinical PD/PDT in North America: an historical review. Photodiagnosis Photodyn Ther. 2004;1:263–277. - PubMed

[5] Lipson RL, Baldes EJ. The photodynamic properties of a particular hematoporphyrin derivative. Arch Dermatol. 1960;82:508–516. - PubMed

[6] Lipson RL, Baldes EJ. The photodynamic properties of a particular hematoporphyrin derivative. Arch Dermatol. 1960;82:508–516. - PubMed

[7] Lipson RL, Baldes EJ. Photosensitivity and heat. Arch Dermatol. 1960;82:517–520. - PubMed

[8] Lipson RL, Baldes EJ. Photosensitivity and heat. Arch Dermatol. 1960;82:517–520. - PubMed

[9] Dougherty TJ. Photodynamic therapy (PDT) of malignant tumors. Crit Rev Oncol Hematol. 1984;2:83–116. - PubMed

[10] Dougherty TJ. Photodynamic therapy (PDT) of malignant tumors. Crit Rev Oncol Hematol. 1984;2:83–116. - PubMed

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Photodynamic Therapy (PDT): PDT Mechanisms

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Photodynamic Therapy (PDT): PDT Mechanisms

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