Carboxylated SiO2-coated α-Fe nanoparticles: towards a versatile platform for biomedical applications

Chem Commun (Camb). 2013 Mar 28;49(25):2563-5. doi: 10.1039/c3cc39055a.


Carboxylated SiO2-coated α-Fe nanoparticles have been successfully prepared via CaH2-mediated reduction of SiO2-coated Fe3O4 nanoparticles followed by surface carboxylation. These α-Fe-based nanoparticles, which are characterized by ease of coating with additional functional groups, a large magnetization of 154 emu per g-Fe, enhanced corrosion resistivity, excellent aqueous dispersibility, and low cytotoxicity, have potential to be a versatile platform in biomedical applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CHO Cells
  • Carboxylic Acids / chemistry*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cricetinae
  • Cricetulus
  • Ferrosoferric Oxide / chemistry*
  • Humans
  • Magnetic Resonance Imaging
  • Magnetite Nanoparticles / chemistry*
  • Magnetite Nanoparticles / toxicity
  • Neoplasms / diagnostic imaging
  • Radiography
  • Silicon Dioxide / chemistry*


  • Carboxylic Acids
  • Magnetite Nanoparticles
  • Silicon Dioxide
  • Ferrosoferric Oxide