Nonrigid medical image registration based on mesh deformation constraints

Comput Math Methods Med. 2013;2013:373082. doi: 10.1155/2013/373082. Epub 2013 Feb 3.


Regularizing the deformation field is an important aspect in nonrigid medical image registration. By covering the template image with a triangular mesh, this paper proposes a new regularization constraint in terms of connections between mesh vertices. The connection relationship is preserved by the spring analogy method. The method is evaluated by registering cerebral magnetic resonance imaging (MRI) image data obtained from different individuals. Experimental results show that the proposed method has good deformation ability and topology-preserving ability, providing a new way to the nonrigid medical image registration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Brain / pathology*
  • Brain Mapping / methods*
  • Computer Simulation
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional / methods
  • Magnetic Resonance Imaging / methods*
  • Models, Statistical
  • Protein Conformation
  • Reproducibility of Results
  • Software
  • Subtraction Technique*