Central line associated blood stream infection related to cooling catheter in cardiac arrest survivors undergoing therapeutic hypothermia by endovascular cooling

Conn Med. 2013 Jan;77(1):35-41.

Abstract

Introduction: The risk of central line associated blood stream infections (CLABSI) related to cooling catheters used for therapeutic hypothermia (TH) is unclear.

Methods: We performed a retrospective analysis on 131 cardiac arrest survivors between 2007 and 2010, who underwent TH by femorally placed endovascular cooling catheter. All patients received prophylactic intravenous ampicillin-sulbactam for 72 hours to reduce the risk of aspiration pneumonia. Cooling catheter related CLABSI and other infections over a period of seven days from initiation of TH were estimated.

Results: Of a total 131 patients, 16 (12%) patients had bacteremia or infection prior to initiation of TH and were excluded. Of the remaining 115 (88%) patients, zero (0%) patients had cooling catheter related CLABSI and 23 (20%) patients had other infections during the study period.

Conclusion: In cardiac arrest survivors undergoing TH, femorally placed endovascular cooling catheter is not associated with an increased incidence of CLABSI.

MeSH terms

  • Aged
  • Ampicillin / administration & dosage
  • Anti-Bacterial Agents / administration & dosage
  • Catheter-Related Infections / drug therapy
  • Catheter-Related Infections / etiology*
  • Catheterization, Central Venous / adverse effects*
  • Catheterization, Central Venous / methods
  • Cross Infection / drug therapy
  • Cross Infection / etiology*
  • Endovascular Procedures
  • Female
  • Heart Arrest / therapy*
  • Humans
  • Hypothermia, Induced / methods*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Sepsis / drug therapy
  • Sepsis / etiology*
  • Sulbactam / administration & dosage

Substances

  • Anti-Bacterial Agents
  • sultamicillin
  • Ampicillin
  • Sulbactam