Criteria for an updated classification of human transcription factor DNA-binding domains

J Bioinform Comput Biol. 2013 Feb;11(1):1340007. doi: 10.1142/S0219720013400076. Epub 2013 Jan 16.


By binding to cis-regulatory elements in a sequence-specific manner, transcription factors regulate the activity of nearby genes. Here, we discuss the criteria for a comprehensive classification of human TFs based on their DNA-binding domains. In particular, classification of basic leucine zipper (bZIP) and zinc finger factors is exemplarily discussed. The resulting classification can be used as a template for TFs of other biological species.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Binding Sites
  • DNA / genetics*
  • DNA-Binding Proteins / genetics*
  • Humans
  • Protein Binding
  • Protein Structure, Tertiary
  • Software*
  • Transcription Factors / genetics*


  • DNA-Binding Proteins
  • Transcription Factors
  • DNA