Gadolinium-DTPA-enhanced magnetic resonance imaging in optic neuropathies

Ophthalmology. 1990 May;97(5):592-9; discussion 599-600.


Magnetic resonance imaging (MRI), after intravenous administration of the paramagnetic agent gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA), showed enhancement of the optic nerve in 7 of 13 patients with acute optic neuritis. Four of these patients had Gd-DTPA enhancement of the intracranial optic nerve and two had involvement of the optic nerve at the orbital apex, ipsilateral to the eye with visual loss. Gadolinium-DTPA enhancement of both intracranial optic nerves was seen in one of two patients with bilateral retrobulbar neuritis. Two patients with acute radiation-induced optic neuropathy also had Gd-DTPA enhancement of the intracranial optic nerve. The authors recommend MRI with Gd-DTPA as the neuro-diagnostic procedure of choice for visualization of increased permeability of the blood-brain barrier in acute optic neuritis and radiation-induced optic neuropathy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Female
  • Gadolinium DTPA
  • Humans
  • Image Enhancement / methods*
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Optic Nerve Diseases / diagnosis*
  • Optic Nerve Diseases / etiology
  • Optic Neuritis / diagnosis*
  • Organometallic Compounds*
  • Pentetic Acid*
  • Radiotherapy / adverse effects
  • Visual Acuity


  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium DTPA