Review on CFD simulation in heart with dilated cardiomyopathy and myocardial infarction

Comput Biol Med. 2013 May;43(4):377-85. doi: 10.1016/j.compbiomed.2013.01.013. Epub 2013 Feb 18.


The heart is a sophisticated functional organ that plays a crucial role in the blood circulatory system. Hemodynamics within the heart chamber can be indicative of exert cardiac health. Due to the limitations of current cardiac imaging modalities, computational fluid dynamics (CFD) have been widely used for the purposes of cardiac function assessment and heart disease diagnosis, as they provide detailed insights into the cardiac flow field. An understanding of ventricular hemodynamics and pathological severities can be gained through studies that employ the CFD method. In this research the hemodynamics of two common myocardial diseases, dilated cardiomyopathy (DCM) and myocardial infarction (MI) were investigated, during both the filling phase and the whole cardiac cycle, through a prescribed geometry and fluid structure interaction (FSI) approach. The results of the research indicated that early stage disease identification and the improvement of cardiac assisting devices and therapeutic procedures can be facilitated through the use of the CFD method.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Algorithms
  • Blood Flow Velocity
  • Cardiomyopathy, Dilated / pathology*
  • Computer Simulation
  • Heart / physiology
  • Heart Failure / physiopathology
  • Heart Ventricles / physiopathology
  • Hemodynamics
  • Humans
  • Hydrodynamics*
  • Models, Cardiovascular
  • Myocardial Infarction / pathology*
  • Myocardial Infarction / physiopathology*
  • Myocardium / pathology
  • Thrombosis / pathology
  • Ventricular Function, Left / physiology