Early amniocentesis: experience of 222 consecutive patients, 1987-1988

Prenat Diagn. 1990 Feb;10(2):79-83. doi: 10.1002/pd.1970100203.


Early amniocentesis from 9 to 14 weeks' gestation provides a safe and accurate method of prenatal diagnosis of cytogenetic and biochemical disorders. There was a 100 per cent success rate in culturing the amniotic cells from 222 samples obtained between 9 and 14 weeks' gestation. Follow-up of the patients to delivery revealed an abortion rate of 1.4 per cent. Among the 207 live- and stillborn infants, only one had a congenital abnormality (bilateral talipes equino-varus) and no infant had respiratory distress syndrome or pneumonia. Eleven pregnancies were terminated following the detection of a chromosomal, biochemical, or congenital abnormality (5.0 per cent). However, before the procedure of early amniocentesis becomes routine clinical practice, it requires appraisal by a randomized clinical trial.

MeSH terms

  • Amniocentesis*
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Trimester, First
  • Prenatal Diagnosis*