Fibroblast growth factor-2, bone homeostasis and fracture repair

Curr Pharm Des. 2013;19(19):3354-63. doi: 10.2174/1381612811319190002.


There remains a great need to develop therapeutic agents to treat critical size defects and non-union fractures and one of the potential agents is recombinant human fibroblast growth factor 2 (FGF-2). We discuss the function of FGF-2 in bone formation, bone resorption, and downstream signaling pathways and review the role of exogenous FGF-2 in fracture healing. The importance of endogenous FGF-2 in bone formation and its potential importance in fracture healing in response to parathyroid hormone (PTH) and bone morphogenetic protein 2 (BMP2) is described. In addition we will review, FGF-2 signaling crosstalk with Wnt signaling and PTH signaling in bone formation and repair. Finally, we discuss the outstanding unresolved issues in the application of FGF-2 as therapeutic agent for bone regeneration.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Bone Regeneration / drug effects
  • Bone Regeneration / physiology
  • Fibroblast Growth Factor 2 / genetics
  • Fibroblast Growth Factor 2 / metabolism
  • Fibroblast Growth Factor 2 / physiology*
  • Fibroblast Growth Factor 2 / therapeutic use*
  • Fracture Healing / drug effects
  • Fracture Healing / physiology*
  • Fractures, Bone / drug therapy*
  • Fractures, Bone / metabolism
  • Homeostasis* / physiology
  • Humans
  • Parathyroid Hormone / metabolism
  • Parathyroid Hormone / physiology
  • Parathyroid Hormone / therapeutic use
  • Signal Transduction
  • Wnt Proteins / metabolism
  • Wnt Proteins / physiology


  • Parathyroid Hormone
  • Wnt Proteins
  • Fibroblast Growth Factor 2