Maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood acute lymphoblastic leukemia

Leuk Res. 2013 May;37(5):531-5. doi: 10.1016/j.leukres.2013.01.020. Epub 2013 Feb 20.


Discovering genetic predictors of childhood acute lymphoblastic leukemia (ALL) necessitates the evaluation of novel factors including maternal genetic effects, which are a proxy for the intrauterine environment, and robust epidemiologic study designs. Therefore, we evaluated five maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood ALL among 120 case-parent triads. Two of the five haplotypes were significantly associated with risk: GSTM3/GSTM4 (P=0.01) and GSTP1 (P=0.02). The EPHX1 haplotype was marginally associated with risk (P=0.05), whereas haplotypes in CYP1B1 and GSTA4 were not. Our results suggest genetic variation in xenobiotic metabolism is important in childhood ALL etiology.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aryl Hydrocarbon Hydroxylases* / genetics
  • Aryl Hydrocarbon Hydroxylases* / metabolism
  • Child
  • Child, Preschool
  • Cytochrome P-450 CYP1B1
  • Epoxide Hydrolases* / genetics
  • Epoxide Hydrolases* / metabolism
  • Female
  • Genetic Variation*
  • Glutathione Transferase* / genetics
  • Glutathione Transferase* / metabolism
  • Haplotypes*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Maternal-Fetal Exchange / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / enzymology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics
  • Pregnancy
  • Retrospective Studies
  • Xenobiotics / metabolism


  • Xenobiotics
  • Aryl Hydrocarbon Hydroxylases
  • CYP1B1 protein, human
  • Cytochrome P-450 CYP1B1
  • Glutathione Transferase
  • Epoxide Hydrolases
  • EPHX1 protein, human
  • leukotriene-C4 synthase