Control of the epithelial stem cell epigenome: the shaping of epithelial stem cell identity

Curr Opin Cell Biol. 2013 Apr;25(2):162-9. doi: 10.1016/ Epub 2013 Feb 19.


The squamous epithelium covering the skin and oral mucosa relies on epithelial stem cells for tissue renewal. Dynamic changes in DNA methylation, histone methylation and acetylation, and higher order chromatin structure are required to preserve their self-renewal capacity while orchestrating the timely execution of cell differentiation programs. This complex network of epigenetic modifications shapes the epithelial stem cell identity and fate. Pathological alterations can be perceived by aberrant chromatin sensors, such as the INK4/ARF locus, which initiate tumor suppressive cell senescence programs, and can often result in epithelial stem cell exhaustion. Unveiling the mechanisms controlling the epigenome in epithelial stem cells may help protect against the loss of their tissue regenerative capacity, thereby preventing premature aging without increasing cancer risk.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / genetics*
  • Chromatin / genetics
  • Chromatin / metabolism
  • Chromatin / pathology
  • Cyclin-Dependent Kinase Inhibitor p16 / metabolism
  • DNA Methylation
  • Epigenesis, Genetic*
  • Epigenomics
  • Epithelial Cells / cytology*
  • Epithelial Cells / metabolism*
  • Histones / chemistry
  • Histones / metabolism
  • Humans
  • Methylation
  • Stem Cells / cytology*
  • Stem Cells / metabolism*
  • Tumor Suppressor Protein p14ARF / metabolism


  • Chromatin
  • Cyclin-Dependent Kinase Inhibitor p16
  • Histones
  • Tumor Suppressor Protein p14ARF