Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder

Nat Neurosci. 2013 Apr;16(4):386-7. doi: 10.1038/nn.3344. Epub 2013 Feb 24.


Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Corpus Striatum / physiology*
  • Deep Brain Stimulation* / methods
  • Female
  • Frontal Lobe / physiology*
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Nerve Net / physiology*
  • Obsessive-Compulsive Disorder / physiopathology*
  • Obsessive-Compulsive Disorder / psychology
  • Obsessive-Compulsive Disorder / therapy*
  • Photic Stimulation / methods
  • Psychomotor Performance / physiology