The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses

Nat Immunol. 2013 Apr;14(4):364-71. doi: 10.1038/ni.2541. Epub 2013 Feb 24.

Abstract

Dendritic cells (DCs) are critical in immune responses, linking innate and adaptive immunity. We found here that DC-specific deletion of the transcription factor STAT5 was not critical for development but was required for T helper type 2 (TH2), but not TH1, allergic responses in both the skin and lungs. Loss of STAT5 in DCs led to the inability to respond to thymic stromal lymphopoietin (TSLP). STAT5 was required for TSLP-dependent DC activation, including upregulation of the expression of costimulatory molecules and chemokine production. Furthermore, TH2 responses in mice with DC-specific loss of STAT5 resembled those seen in mice deficient in the receptor for TSLP. Our results show that the TSLP-STAT5 axis in DCs is a critical component for the promotion of type 2 immunity at barrier surfaces.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Differentiation
  • Cytokines / immunology
  • Cytokines / metabolism
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism*
  • Dermatitis, Contact / immunology
  • Dermatitis, Contact / metabolism
  • Dermis / immunology
  • Dermis / metabolism
  • Female
  • Homeostasis / immunology
  • Janus Kinases / metabolism
  • Lung / immunology
  • Lung / metabolism
  • Mice
  • Mice, Knockout
  • STAT5 Transcription Factor / genetics
  • STAT5 Transcription Factor / metabolism*
  • Signal Transduction
  • Th1 Cells / immunology
  • Th2 Cells / immunology*

Substances

  • Cytokines
  • STAT5 Transcription Factor
  • Janus Kinases
  • thymic stromal lymphopoietin