Myocyte enhancer factor 2C in hematopoiesis and leukemia

Oncogene. 2014 Jan 23;33(4):403-10. doi: 10.1038/onc.2013.56. Epub 2013 Feb 25.


MEF2C is a selectively expressed transcription factor involved in different transcriptional complexes. Originally identified as an essential regulator of muscle development, ectopic expression of MEF2C as a result of chromosomal rearrangements is now linked to leukemia. Specifically, high MEF2C expression has been linked to mixed lineage leukemia-rearranged acute myeloid leukemia as well as to the immature subgroup of T-cell acute lymphoblastic leukemia. This review focuses on the role of MEF2C in the hematopoietic system and on aberrant MEF2C expression in human leukemia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Hematopoiesis / genetics*
  • Humans
  • Leukemia / genetics*
  • Leukemia / metabolism
  • MEF2 Transcription Factors / genetics
  • MEF2 Transcription Factors / metabolism


  • MEF2 Transcription Factors
  • MEF2C protein, human