Cancer of unknown primary sites: what radiologists need to know and what oncologists want to know

AJR Am J Roentgenol. 2013 Mar;200(3):484-92. doi: 10.2214/AJR.12.9363.


Objective: In this article, we review the role of imaging in cancer of unknown primary site (CUP) diagnosis and management and the utility of immunohistochemistry, serum tumor markers, and molecular profiling in the optimized care of CUP patients.

Conclusion: With advances in imaging, pathology, and molecular medicine, the diagnosis and management of CUP have evolved into more personalized and site-specific therapies. A multidisciplinary integrated approach among oncologists, pathologists, and radiologists is extremely important.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Diagnostic Imaging / trends*
  • Humans
  • Image Enhancement / methods*
  • Neoplasms, Unknown Primary / diagnosis*
  • Pathology, Molecular / trends*