Expression and differential response to haloperidol treatment of Cyclon/CCDC86 mRNA in schizophrenia patients

Neurochem Int. 2013 May;62(6):870-2. doi: 10.1016/j.neuint.2013.02.017. Epub 2013 Feb 21.


A gene known as Cyclon (cytokine-induced protein with coiled-coil domain) or CCDC86 (coiled-coil domain-containing protein 86) is known for its expression in leukocytes in mice, where it regulates the immune response. We investigated whether Cyclon/CCDC68 is expressed in leukocytes of schizophrenia patients and whether it might be used as a biological marker for the disease endophenotype segregation. We examined the level of mRNA of Cyclon/CCDC68 in white blood cells obtained from schizophrenia patients in relapse and remission as well as in healthy controls. The mRNA of Cyclon/CCDC68 was expressed by white blood cells of both schizophrenia patients and healthy controls. There was a dichotomous change in the levels of Cyclon/CCDC68 of relapsed patients before and after treatment. High Cyclon/CCDC68 levels were associated with a recent disease and presence of psychotic symptoms, while low levels were associated with a long duration of the disease and an absence of psychotic symptoms. These data indicate that Cyclon/CCDC68 levels correlate with the clinical presentation of relapsed schizophrenia. Cyclon/CCDC68 might be involved in the immune system disturbances observed in schizophrenia.

MeSH terms

  • Adult
  • Antipsychotic Agents / pharmacology*
  • Antipsychotic Agents / therapeutic use
  • Female
  • Haloperidol / pharmacology*
  • Haloperidol / therapeutic use
  • Humans
  • Leukocytes / drug effects
  • Leukocytes / immunology
  • Leukocytes / metabolism
  • Male
  • Middle Aged
  • Nuclear Proteins / biosynthesis*
  • Nuclear Proteins / genetics*
  • Polymerase Chain Reaction
  • RNA, Messenger / genetics*
  • RNA-Binding Proteins
  • Schizophrenia / drug therapy
  • Schizophrenia / immunology
  • Schizophrenia / metabolism*
  • Treatment Outcome
  • Young Adult


  • Antipsychotic Agents
  • CCDC86 protein, human
  • Nuclear Proteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • Haloperidol