Thermoresponsive Diblock Copolymer With Tunable Soluble-Insoluble and Soluble-Insoluble-Soluble Transitions

Macromol Rapid Commun. 2013 Apr 12;34(7):574-80. doi: 10.1002/marc.201200785. Epub 2013 Feb 26.


The thermoresponsive transition behavior of a diblock copolymer consisting of poly(ethylene glycol) methyl ether (mPEG) and poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) in aqueous solutions has been investigated. With a specific composition, the copolymer showed a unique tunable phase transition from no response in acidic media to a soluble-insoluble (S-I) transition in neutral media and an S-I-S transition in basic media either in the presence of salt or for salt-free solutions. The S-I-S transition can be tuned over a wide temperature range even to an S-I type transition just by adding salts. In addition, phase transitions can occur in both pure water and saline solution under practical conditions (30-80 °C), which makes them suitable for a broad range of applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry
  • Methacrylates / chemistry*
  • Nylons / chemistry*
  • Phase Transition
  • Polyethylene Glycols / chemistry*
  • Solubility
  • Temperature
  • Thermodynamics


  • Biocompatible Materials
  • Methacrylates
  • Nylons
  • poly(2-(dimethylamino)ethyl methacrylate)
  • Polyethylene Glycols