Stability studies with amphotericin B and amphotericin B methyl ester

J Antibiot (Tokyo). 1975 Feb;28(2):132-5. doi: 10.7164/antibiotics.28.132.

Abstract

In solid form, amphotericin B and amphotericin B methyl ester free base exhibit similar stability. Acid salts of the methyl ester derivative stored under identical conditions are less stable. In solution, amphotericin B is generally more stable than its methy ester salts. However, when pH is adjusted to 6.0 and storage temperature held at 5 degrees C the methyl ester salts reflect the stability exhibited by the parent compound, amphotericin B.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amphotericin B* / pharmacology
  • Drug Stability
  • Esters
  • Hydrogen-Ion Concentration
  • Saccharomyces cerevisiae / drug effects
  • Solubility
  • Temperature
  • Time Factors

Substances

  • Esters
  • Amphotericin B