[Ethyl benzimidazole carbamate: teratogenic effect and presence in the milk of cows after administration of thiophanate]

Ann Rech Vet. 1990;21(1):87-92.
[Article in French]

Abstract

After oral administration of 40 mg/kg of thiophanate to dairy cows, the active metabolite, ethyl-1H-benzimidazol-2-yl carbamate (EBC) reached a maximal concentration of 0.44 microgram/ml during the first milking and was eliminated by the mammary gland after 60 h. BCE is teratogenic in rats at doses of over 6.8 mg/kg while thiophanate at doses of up to 148 mg/kg is not. These results indicate that thiophanate treatment for dairy cattle may be questionable.

Publication types

  • English Abstract

MeSH terms

  • Abnormalities, Drug-Induced / veterinary*
  • Administration, Oral
  • Animals
  • Benzimidazoles / analysis*
  • Benzimidazoles / toxicity
  • Carbamates / pharmacokinetics*
  • Cattle / metabolism*
  • Female
  • Mammary Glands, Animal / metabolism*
  • Milk / analysis*
  • Pregnancy
  • Rats
  • Rats, Inbred Strains
  • Thiophanate / administration & dosage
  • Thiophanate / pharmacokinetics*

Substances

  • Benzimidazoles
  • Carbamates
  • Thiophanate
  • lobendazole