Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line

Nutr Cancer. 2013;65(2):296-304. doi: 10.1080/01635581.2013.756920.

Abstract

Lung cancer is one of the leading causes of death worldwide. We investigated the molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cells by cell cycle, viability, cytokines, calcium ion and gene expression analysis. Acacia honey inhibited cells proliferation, arrested G0/G1 phase, stimulated cytokines, calcium ion release as well as suppressed p53 and Bcl-2 expression in a dose-dependent manner. We proposed that the molecular mechanism of the antiproliferation potential of Acacia honey on NCI-H460 cell line is due to cell cycle arrest, stimulation of cytokines and calcium ion as well as downregulation of Bcl-2 and p53 genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acacia*
  • Antineoplastic Agents / pharmacology*
  • Calcium / metabolism
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cytokines / metabolism
  • G1 Phase Cell Cycle Checkpoints / drug effects
  • Gene Expression Regulation, Neoplastic / drug effects
  • Genes, bcl-2
  • Genes, p53
  • Honey*
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / pathology

Substances

  • Antineoplastic Agents
  • Cytokines
  • Calcium