[Efficacy of percutaneous caffeine in the treatment of apnea in the premature infant]

Arch Fr Pediatr. 1990 Mar;47(3):221-4.
[Article in French]


In 18 prematures (gestational age less than 32 weeks), an aqueous monohydrated caffeine colloidal gel was administered topically. High plasma levels were rapidly obtained with a loading dose divided in 4 applications by massaging, 1 ml of gel per kg body weight, at 12 hour intervals (18 mg caffeine base/kg). Maintenance was then instituted with a dose of 0.5 ml/kg/day. Treatment was initiated before 8 days of life, in children under assisted ventilation but without severe pulmonary involvement, during the period of weaning from the respirator. A good local and general tolerance was invariably observed and remarkable therapeutic efficacy was obtained.

Publication types

  • English Abstract

MeSH terms

  • Administration, Cutaneous
  • Apnea / drug therapy*
  • Apnea / prevention & control
  • Caffeine / administration & dosage
  • Caffeine / blood
  • Caffeine / therapeutic use*
  • Humans
  • Infant, Newborn
  • Infant, Premature, Diseases / drug therapy*
  • Massage


  • Caffeine