Prospective in vitro testing for drug-induced neutropenia in a patient requiring anti-malarial prophylaxis: confirmation of findings on exposure of patient to drug

Clin Lab Haematol. 1990;12(1):31-6. doi: 10.1111/j.1365-2257.1990.tb01107.x.


A patient with moderate pancytopenia thought to be due to chloroquine ingestion was shown to have granulocyte progenitors (CFU-G) which were abnormally sensitive in vitro to chloroquine. As he required further anti-malarial prophylaxis, his marrow was prospectively tested in vitro with proguanil and its metabolite cycloguanil. The patient's CFU-G were also abnormally sensitive to these agents and predicted neutropenia was verified when the patient had a trial course of proguanil. We believe this is the first instance of in vivo confirmation of in vitro CFU-G drug sensitivities.

Publication types

  • Case Reports

MeSH terms

  • Agranulocytosis / diagnosis*
  • Bone Marrow / pathology
  • Cells, Cultured
  • Chloroquine / adverse effects*
  • Colony-Forming Units Assay
  • Humans
  • Malaria / prevention & control*
  • Male
  • Middle Aged
  • Neutropenia / chemically induced
  • Neutropenia / diagnosis*
  • Proguanil / adverse effects
  • Prospective Studies


  • Chloroquine
  • Proguanil