Mitochondrial dysfunction and oxidative stress in insulin resistance

Curr Pharm Des. 2013;19(32):5730-41. doi: 10.2174/13816128113199990373.

Abstract

Evidence is mounting of the involvement of mitochondrial dysfunction in insulin resistance, diabetes and associated complications. This review aims to provide an overview of the effects of insulin resistance on mitochondrial function in several tissues. We consider the pathogenesis of insulin resistance from a mitochondrial perspective and contemplate potential beneficial effects of strategies aimed at modulating mitochondrial function in insulin resistance, including insulin and insulin-sensitizing drugs, antioxidants, and selectively targeting antioxidants to mitochondria.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antioxidants / metabolism
  • Antioxidants / pharmacology
  • Diabetes Complications / physiopathology
  • Diabetes Mellitus / physiopathology
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Insulin / administration & dosage
  • Insulin / metabolism
  • Insulin Resistance*
  • Mitochondria / pathology*
  • Molecular Targeted Therapy
  • Oxidative Stress*

Substances

  • Antioxidants
  • Hypoglycemic Agents
  • Insulin