A CRISPR way to engineer the human genome

Genome Biol. 2013 Feb 26;14(2):107. doi: 10.1186/gb-2013-14-2-107.


RNA-guided genome engineering based on the type II prokaryotic CRISPR/Cas system provides an efficient and versatile method for targeted manipulation of mammalian genomes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • CRISPR-Cas Systems*
  • Genetic Engineering / methods*
  • Genome, Human*
  • Humans