Primary penile lymphoma: the use of PET-CT for accurate staging and response monitoring

Diagn Interv Radiol. 2013 Mar-Apr;19(2):130-3. doi: 10.4261/1305-3825.DIR.6253-12.1.


Primary penile lymphoma is an extremely rare neoplasm. We present a case of 63-year-old man with painless diffuse pe- nile swelling and retention of urine. Biopsy from the penile swelling demonstrated CD20+ diffuse large B-cell lymphoma. Staging was performed using fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) and revealed a FDG avid penile mass with enlarged and FDG avid multiple inguinal and aortocaval lymph nodes. A follow-up FDG PET-CT scan after eight cycles of combination chemotherapy showed complete remission of the dis- ease. Thus, FDG PET-CT should be integrated in management protocols of rare primary penile lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Fluorodeoxyglucose F18
  • Follow-Up Studies
  • Humans
  • Lymphoma, Large B-Cell, Diffuse / diagnosis*
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Penile Neoplasms / diagnosis*
  • Penile Neoplasms / drug therapy
  • Penile Neoplasms / pathology*
  • Penis / diagnostic imaging
  • Positron-Emission Tomography / methods*
  • Radiopharmaceuticals
  • Tomography, X-Ray Computed / methods*
  • Treatment Outcome


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18