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, 33 (8), 622-6

Low Immature Platelet Fraction Suggests Decreased Megakaryopoiesis in Neonates With Sepsis or Necrotizing Enterocolitis

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Low Immature Platelet Fraction Suggests Decreased Megakaryopoiesis in Neonates With Sepsis or Necrotizing Enterocolitis

M Cremer et al. J Perinatol.

Abstract

Objective: In order to conclude on the megakaryopoietic activity during thrombocytopenia in sepsis or necrotizing enterocolitis (NEC), we analyzed the immature platelet fraction (IPF).

Study design: Serial measurements of platelet counts and IPF in neonates with blood culture-proven late-onset sepsis (n=21) or surgical NEC (n=12) at T0: prior to the diagnosis of sepsis/NEC; T1: at diagnosis; T2: days 3 to 5 after onset; T3: days 8 to 12 after onset.

Result: In parallel to declining platelet counts, the median absolute IPF significantly decreased between T0 and T2 in neonates with sepsis or NEC. We found a significant positive correlation between the platelet count and absolute IPF (r=0.71; P<0.001). In patients with low IPF (<2 per nl), the platelet count did not subsequently increase. Neonates with NEC who died exhibited significantly lower IPF compared with survivors (P<0.05).

Conclusion: Low absolute IPF values during the course of neonatal sepsis/NEC suggest suppression of megakaryopoietic activity.

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