Acute disseminated encephalomyelitis in two renal transplant patients: is there a role for Epstein-Barr virus reactivation?

Mult Scler. 2013 Aug;19(9):1222-5. doi: 10.1177/1352458513478674. Epub 2013 Feb 28.


Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory demyelinating disease of the central nervous system, usually occurring after a vaccination or infectious disease. It has been exceptionally described in transplanted patients. The pathophysiology remains incompletely understood. We report the clinical, biological and magnetic resonance imaging (MRI) presentation and evolution of two kidney-transplanted patients with ADEM associated with local Epstein-Barr virus (EBV) reactivation. ADEM may occur in transplanted patients with favorable evolution. Its pathophysiology is uncertain, and the implication of EBV is discussed.

Keywords: Epstein-Barr virus; acute disseminated encephalomyelitis; immunodeficiency; kidney; physiopathology; transplantation.

Publication types

  • Case Reports

MeSH terms

  • Encephalomyelitis, Acute Disseminated / immunology*
  • Encephalomyelitis, Acute Disseminated / virology*
  • Epstein-Barr Virus Infections / complications
  • Epstein-Barr Virus Infections / immunology*
  • Female
  • Herpesvirus 4, Human / physiology*
  • Humans
  • Immunocompromised Host / immunology*
  • Kidney Transplantation / adverse effects*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Virus Activation* / immunology