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. 2012 Sep;10(3):254-62.
doi: 10.2174/157015912803217341.

Post-stroke Movement Disorders: Clinical Manifestations and Pharmacological Management

Antonio Siniscalchi  1 , Luca Gallelli, Angelo Labate, Giovanni Malferrari, Caterina Palleria, Giovambattista De Sarro
Affiliations
Free PMC article

Post-stroke Movement Disorders: Clinical Manifestations and Pharmacological Management

Antonio Siniscalchi et al. Curr Neuropharmacol. 2012 Sep.
Free PMC article

Abstract

Involuntary abnormal movements have been reported after ischaemic and haemorrhagic stroke. Post stroke movement disorders can appear as acute or delayed sequel. At the moment, for many of these disorders the knowledge of pharmacological treatment is still inadequate. Dopaminergic and GABAergic systems may be mainly involved in post-stroke movement disorders. This article provides a review on drugs commonly used in post-stroke movement disorders, given that some post-stroke movement disorders have shown a partial benefit with pharmacological approach.

Keywords: Dopamine; GABA; Post-stroke; hyperkinetic movements disorders; hypokinetic movements disorders; movement disorders; post-stroke recovery..

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Figures

Fig. (1)
Fig. (1)
Representation of neuronal connections in the basal ganglia. Broken lines represent inhibitory connections, and unbroken lines represent stimulatory connections. SNc: substantial nigra pars compacta; GPi: globus pallidus pars interna; STn: subthalamus nucleus; SNr: substantial nigra pars reticulate; GPe: globus pallidus pars externa. DA: dopamine; Glut: glutamate; GABA: gamma-aminobutyric acid A.
See this image and copyright information in PMC

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