Abstract
Environmental compounds have been shown to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a hydrocarbon mixture involving jet fuel (JP-8) promotes epigenetic transgenerational inheritance of disease. Gestating F0 generation female rats were transiently exposed during the fetal gonadal development period. The direct exposure F1 generation had an increased incidence of kidney abnormalities in both females and males, prostate and pubertal abnormalities in males, and primordial follicle loss and polycystic ovarian disease in females. The first transgenerational generation is the F3 generation, and the jet fuel lineage had an increased incidence of primordial follicle loss and polycystic ovarian disease in females, and obesity in both females and males. Analysis of the jet fuel lineage F3 generation sperm epigenome identified 33 differential DNA methylation regions, termed epimutations. Observations demonstrate hydrocarbons can promote epigenetic transgenerational inheritance of disease and sperm epimutations, potential biomarkers for ancestral exposures.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Abnormalities, Drug-Induced / metabolism
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Abnormalities, Drug-Induced / pathology
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Abnormalities, Multiple / chemically induced
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Abnormalities, Multiple / metabolism
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Abnormalities, Multiple / pathology
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Animals
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DNA Methylation / drug effects
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Epigenesis, Genetic / drug effects*
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Female
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Genitalia, Male / abnormalities
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Genitalia, Male / drug effects
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Genitalia, Male / metabolism
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Genitalia, Male / pathology
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Hydrocarbons / toxicity*
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Infertility, Female / chemically induced*
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Infertility, Female / genetics
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Infertility, Female / metabolism
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Infertility, Female / pathology
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Infertility, Male / chemically induced*
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Infertility, Male / genetics
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Infertility, Male / metabolism
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Infertility, Male / pathology
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Male
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Maternal Exposure / adverse effects*
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Mutagens / toxicity
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Mutation / drug effects
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Obesity / chemically induced*
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Obesity / genetics
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Obesity / metabolism
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Obesity / pathology
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Ovary / abnormalities
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Ovary / drug effects
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Ovary / metabolism
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Ovary / pathology
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Paternal Exposure / adverse effects
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Pregnancy
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Random Allocation
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Rats
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Rats, Sprague-Dawley
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Spermatozoa / drug effects*
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Spermatozoa / metabolism
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Spermatozoa / pathology
Substances
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Hydrocarbons
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JP8 aviation fuel
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Mutagens