Fluorescent probes designed for detecting human serum albumin on the basis of its pseudo-esterase activity

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2093-7. doi: 10.1016/j.bmcl.2013.01.124. Epub 2013 Feb 7.

Abstract

We developed activity-based fluorescent probes for detecting human serum albumin (HSA) on the basis of its pseudo-esterase activity. These probes could also detect HSA in blood-contaminated tissue samples.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Enzyme Activation
  • Esterases / metabolism*
  • Flow Cytometry
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Humans
  • Leukemia, Monocytic, Acute / pathology
  • Microscopy, Fluorescence
  • Models, Molecular
  • Molecular Structure
  • Serum Albumin / analysis*

Substances

  • Fluorescent Dyes
  • Serum Albumin
  • Esterases