Cell cycle regulation of Golgi membrane dynamics

Trends Cell Biol. 2013 Jun;23(6):296-304. doi: 10.1016/j.tcb.2013.01.008. Epub 2013 Feb 28.


The Golgi apparatus is a membranous organelle in the cell that plays essential roles in protein and lipid trafficking, sorting, processing, and modification. Its basic structure is a stack of closely aligned flattened cisternae. In mammalian cells, dozens of Golgi stacks are often laterally linked into a ribbon-like structure. Biogenesis of the Golgi during cell division occurs through a sophisticated disassembly and reassembly process that can be divided into three distinct but cooperative steps, including the deformation and reformation of the Golgi cisternae, stacks, and ribbon. Here, we review our current understanding of the protein machineries that control these three steps in the cycle of mammalian cell division: GRASP65 and GRASP55 in Golgi stack and ribbon formation; ubiquitin and AAA ATPases in postmitotic Golgi membrane fusion; and golgins and cytoskeleton in Golgi ribbon formation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle*
  • Golgi Apparatus / metabolism*
  • Golgi Matrix Proteins
  • Humans
  • Membrane Fusion*
  • Membrane Glycoproteins
  • Membrane Proteins / metabolism*
  • Protein Transport / genetics
  • Ubiquitins / metabolism


  • GORASP1 protein, human
  • GORASP2 protein, human
  • Golgi Matrix Proteins
  • Golgi membrane glycoproteins
  • Membrane Glycoproteins
  • Membrane Proteins
  • Ubiquitins