Regulated unfolding of proteins in signaling

FEBS Lett. 2013 Apr 17;587(8):1081-8. doi: 10.1016/j.febslet.2013.02.024. Epub 2013 Feb 20.


The transduction of biological signals often involves structural rearrangements of proteins in response to input signals, which leads to functional outputs. This review discusses the role of regulated partial and complete protein unfolding as a mechanism of controlling protein function and the prevalence of this regulatory mechanism in signal transduction pathways. The principles of regulated unfolding, the stimuli that trigger unfolding, and the coupling of unfolding with other well characterized regulatory mechanism are discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Models, Biological
  • Models, Molecular
  • Protein Binding
  • Protein Processing, Post-Translational
  • Protein Structure, Tertiary*
  • Protein Unfolding*
  • Proteins / chemistry*
  • Proteins / metabolism
  • Signal Transduction*


  • Proteins