Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages

Life Sci. 2013 Apr 19;92(13):775-82. doi: 10.1016/j.lfs.2013.02.006. Epub 2013 Feb 20.


Aims: The potato glycoalkaloids, α-chaconine, α-solanine and solanidine, along with potato peel extracts were investigated for potential anti-inflammatory effects in vitro. Their potential to reduce two biomarkers of inflammation, cytokine and nitric oxide (NO) productions, were assessed in the stimulated Jurkat and macrophage models, respectively.

Main methods: Cytokine and nitric oxide productions were stimulated in Jurkat and Raw 264.7 macrophages with Concanavalin A (Con A; 25 μg/ml) and lipopolysaccaride (LPS; 1 μg/ml), respectively. Selective concentrations of glycoalkaloids and potato peel extracts were added simultaneously with Con A or LPS for 24h to investigate their potential to reduce inflammatory activity.

Key findings: α-Chaconine and solanidine significantly reduced interleukin-2 (IL-2) and interleukin-8 (IL-8) productions in Con A-induced Jurkat cells. The potato peel extracts did not influence cytokine production. In LPS-stimulated Raw macrophages, α-solanine, solanidine and two potato peel extracts significantly reduced induced NO production.

Significance: Our findings suggest that sub-cytotoxic concentrations of potato glycoalkaloids and potato peel extracts possess anti-inflammatory effects in vitro and with further investigation may be useful in the prevention of anti-inflammatory diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Line
  • Concanavalin A / immunology
  • Diosgenin / pharmacology*
  • Humans
  • Interleukin-2 / immunology
  • Interleukin-8 / immunology
  • Jurkat Cells / drug effects*
  • Jurkat Cells / immunology
  • Lipopolysaccharides / immunology
  • Macrophages / drug effects*
  • Macrophages / immunology
  • Mice
  • Nitric Oxide / immunology
  • Plant Extracts / pharmacology*
  • Solanine / analogs & derivatives*
  • Solanine / pharmacology
  • Solanum tuberosum / chemistry


  • Anti-Inflammatory Agents
  • Interleukin-2
  • Interleukin-8
  • Lipopolysaccharides
  • Plant Extracts
  • alpha-solanine
  • Concanavalin A
  • Solanine
  • alpha-chaconine
  • Nitric Oxide
  • Diosgenin
  • solanidine