Detection of early onset of hypophysitis by (18)F-FDG PET-CT in a patient with advanced stage melanoma treated with ipilimumab

Clin Nucl Med. 2013 Apr;38(4):e182-4. doi: 10.1097/RLU.0b013e3182639765.


Ipilimumab is a human monoclonal antibody directed against a receptor expressed on activated T-lymphocytes (CTLA-4). Binding to this receptor induces T-cell activation against tumor cells. A 77-year-old man with a stage IV metastatic melanoma was treated with ipilimumab. F-FDG PET-CT performed for response evaluation revealed intense uptake in the pituitary gland. Two weeks later, biochemical parameters altered confirming hypophysitis. Treatment of the hypophysitis was started, and shortly thereafter, biochemical parameters normalized. Follow-up PET-CT revealed normalization of F-FDG uptake in the pituitary gland. In this case, we present a patient with ipilimumab-induced hypophysitis initially diagnosed on F-FDG PET-CT.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Monoclonal / adverse effects*
  • Antibodies, Monoclonal / therapeutic use
  • Disease Progression
  • Fluorodeoxyglucose F18*
  • Humans
  • Ipilimumab
  • Male
  • Melanoma / drug therapy*
  • Melanoma / pathology*
  • Multimodal Imaging*
  • Neoplasm Staging
  • Pituitary Diseases / chemically induced*
  • Pituitary Diseases / diagnostic imaging*
  • Positron-Emission Tomography*
  • Tomography, X-Ray Computed*


  • Antibodies, Monoclonal
  • Ipilimumab
  • Fluorodeoxyglucose F18