Abstract
Memory CD8⁺ T cells play an essential role in controlling pathogenic infections. Therefore generating protective memory CD8⁺ T cells by vaccination is an attractive strategy for preventing and treating a variety of human diseases. Understanding what comprises a protective memory CD8⁺ T cell response will help optimize vaccine-induced CD8⁺ T cell immunity. Here we discuss essential antiviral effector functions and highlight how recall expansion of memory CD8⁺ T cells may affect the primary response.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adaptive Immunity
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Animals
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / pathology
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CD4-Positive T-Lymphocytes / virology
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CD8-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / pathology
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CD8-Positive T-Lymphocytes / virology
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Cell Proliferation
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Humans
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Immunologic Memory*
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Smallpox / immunology
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Smallpox / prevention & control*
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Smallpox / virology
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Vaccination*
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Variola virus / immunology