Seizures induced by desloratadine, a second-generation antihistamine: clinical observations

Neuropediatrics. 2013 Aug;44(4):222-4. doi: 10.1055/s-0033-1333871. Epub 2013 Mar 1.


Some clinical experiences indicate that H1-antihistamines, especially first-generation H1-antagonists, occasionally provoke convulsions in healthy children as well as epileptic patients. Desloratadine is a frequently used second-generation antihistamine considered to be effective and safe for the treatment of allergic diseases. We describe four children who experienced epilepsy associated with the nonsedating H(1)-antagonist desloratadine and discuss the neurophysiologic role of the central histaminergic system in seizure susceptibility. In conclusion, we recommend caution in treating epileptic patients with the histamine H(1)-antagonists, including second- and third-generation drugs that are frequently referred because they are considered to be nonsedating antihistamines.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Epilepsy / chemically induced*
  • Female
  • Histamine H1 Antagonists, Non-Sedating / adverse effects*
  • Humans
  • Hypersensitivity / drug therapy
  • Loratadine / adverse effects
  • Loratadine / analogs & derivatives*
  • Male


  • Histamine H1 Antagonists, Non-Sedating
  • Loratadine
  • desloratadine