Protective effect of mango (Mangifera indica L.) against UVB-induced skin aging in hairless mice

Photodermatol Photoimmunol Photomed. 2013 Apr;29(2):84-9. doi: 10.1111/phpp.12030.


Background: Mangifera indica L. (Anacardiaceae) is a medicinal plant whose extracts have been described as an antioxidant with anti-inflammatory and immunomodulatory activities.

Purpose: Skin aging is a consequence of chronic sun exposure to the sun and therefore ultraviolet (UV) radiation. Naturally occurring antioxidants are known to reduce skin aging. Therefore, the aim of the present study was to evaluate the protective role of mango extract against UVB-induced skin aging in hairless mice.

Methods: HR-1 hairless male mice (6 weeks old) were divided into three groups: control (n = 5), UVB-treated vehicle (n = 5), and UVB-treated mango extract (n = 5) groups. UVB-irradiated mice from the mango extract group were orally administered 0.1 ml of water containing 100 mg of mango extract/kg body weight per day. The inhibitory activity of mango extract on wrinkle formation was determined by the analysis of the skin replica, epidermal thickness based on histological examination, and damage to collagen fiber.

Results: The mean length of wrinkles in UVB-treated vehicle group significantly improved after the oral administration of mango extract, which significantly inhibited the increase in epidermal thickness and epidermal hypertrophy (P < 0.05). Furthermore, a marked increase in collagen bundles was observed in the UVB-treated group after the administration of mango extract by Masson's trichrome staining.

Conclusion: These results indicate that mango extract showed anti-photoaging activity in UVB-irradiated hairless mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Collagen / ultrastructure
  • Fruit
  • Male
  • Mangifera*
  • Mice
  • Mice, Hairless
  • Phytotherapy*
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Skin Aging / drug effects*
  • Skin Aging / pathology
  • Skin Aging / radiation effects
  • Ultraviolet Rays / adverse effects
  • Xanthones / pharmacology*
  • Xanthones / therapeutic use


  • Plant Extracts
  • Xanthones
  • mangiferin
  • Collagen