Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling

Mol Aspects Med. 2013 Dec;34(6):1088-108. doi: 10.1016/j.mam.2013.02.002. Epub 2013 Feb 28.


ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, protein degradation, and DNA repair. Modulating the proteins involved in the metabolism of ADP-ribosylation can have therapeutic benefits in various disease states. Protein crystal structures can help understand the biological functions, facilitate detailed analysis of single residues, as well as provide a basis for development of small molecule effectors. Here we review recent advances in our understanding of the structural biology of the writers, readers, and erasers of ADP-ribosylation.

Keywords: ADP-ribosylation; DNA repair; Glycohydrolase; Macro domain; Signaling pathways; Transferase.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ADP Ribose Transferases / chemistry*
  • ADP Ribose Transferases / metabolism*
  • Animals
  • Bacteria / enzymology
  • Binding Sites
  • DNA Damage
  • Gene Expression Regulation
  • Glycoside Hydrolases / chemistry*
  • Glycoside Hydrolases / metabolism*
  • Humans
  • Models, Molecular
  • Poly Adenosine Diphosphate Ribose / chemistry
  • Poly Adenosine Diphosphate Ribose / metabolism*
  • Poly(ADP-ribose) Polymerases / chemistry*
  • Poly(ADP-ribose) Polymerases / metabolism*
  • Protein Interaction Domains and Motifs
  • Protein Processing, Post-Translational
  • Protein Structure, Tertiary
  • Signal Transduction
  • Tankyrases / chemistry
  • Tankyrases / metabolism


  • Poly Adenosine Diphosphate Ribose
  • ADP Ribose Transferases
  • Poly(ADP-ribose) Polymerases
  • Tankyrases
  • Glycoside Hydrolases
  • poly ADP-ribose glycohydrolase