A cohort study of enteric campylobacter infection in children from birth to two years in Bangui (Central African Republic)

Trans R Soc Trop Med Hyg. 1990 Jan-Feb;84(1):122-5. doi: 10.1016/0035-9203(90)90402-z.


A cohort of 111 children from Bangui, Central African Republic, was followed for enteric campylobacter infection from birth until the age of 2 years. Stools were examined at each episode of diarrhoea, and bi-weekly up to the age of 6 months irrespective of the presence of diarrhoea. 349 episodes of diarrhoeal illness were recorded (1.6 per child-year). Campylobacters were isolated from 41 (11.7%) of the 349 episodes, but in half of them another enteric pathogen was also isolated. Campylobacters were statistically associated with diarrhoea only before the age of 6 months. Bi-weekly sampling up to this age detected 75 infections (1.3 per child-year), yet only 12 (16%) were associated with diarrhoea. Campylobacter coli was isolated slightly more often (51%) than C jejuni (49%); biotyping and serogrouping showed that no strain was especially associated with disease. Fewer children who had campylobacter infection before the age of 6 months suffered campylobacter diarrhoea between 6 and 24 months of age than those who did not, but the difference did not reach statistical significance. A significantly higher rate of isolation was found in the homes of infected children (human and animal contacts) than of non-infected children. Campylobacter infections were statistically associated with the presence of live poultry and the lack of piped water in homes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Animals, Domestic
  • Campylobacter / isolation & purification
  • Campylobacter Infections / epidemiology*
  • Campylobacter Infections / microbiology
  • Central African Republic / epidemiology
  • Cohort Studies
  • Diarrhea, Infantile / epidemiology
  • Diarrhea, Infantile / microbiology
  • Feces / microbiology
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Water Supply