In vivo binding of the dopamine-1 receptor PET tracers [¹¹C]NNC112 and [¹¹C]SCH23390: a comparison study in individuals with schizophrenia

Psychopharmacology (Berl). 2013 Jul;228(1):167-74. doi: 10.1007/s00213-013-3026-8. Epub 2013 Mar 5.


Rationale: A deficit in dopamine-1 (D1) receptor function in the prefrontal cortex is suggested to play a role in the cognitive dysfunction observed in patients with schizophrenia. However, the results from positron emission tomography imaging studies of D1 receptor levels in individuals with schizophrenia are mixed.

Objectives: The aim of this investigation was to determine whether the in vivo characteristics of the different D1 receptor tracers used in previous reports, [(11)C]SCH23390 and [(11)C]NNC112, may have contributed to these discrepancies reported in the literature.

Methods: Eight patients with schizophrenia and 12 healthy control subjects were scanned with both [(11)C]SCH23390 and [(11)C]NNC112.

Results: [(11)C]SCH23390 and [(11)C]NNC112 binding potentials in both patients and control subjects were compared and no tracer by diagnosis interactions were observed.

Conclusions: The results of this study suggest that differences in the binding of [(11)C]SCH23390 and [(11)C]NNC112 observed in previous studies are not due to differences in the in vivo behavior of these tracers.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Benzazepines / metabolism*
  • Benzofurans / metabolism*
  • Carbon Radioisotopes / metabolism
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Positron-Emission Tomography / methods*
  • Radioactive Tracers
  • Radiopharmaceuticals / metabolism
  • Receptors, Dopamine D1 / metabolism
  • Schizophrenia / physiopathology*
  • Young Adult


  • Benzazepines
  • Benzofurans
  • Carbon Radioisotopes
  • Radioactive Tracers
  • Radiopharmaceuticals
  • Receptors, Dopamine D1
  • SCH 23390
  • NNC 112