Melanosis coli--histochemical and immunohistochemical comparison of the pigments of melanosis coli and Dubin-Johnson syndrome

Yonsei Med J. 1990 Mar;31(1):27-32. doi: 10.3349/ymj.1990.31.1.27.


We compared the pigment of melanosis coli with the pigment of Dubin-Johnson syndrome, melanin, and lipofuscin. The pigment of melanosis coli appeared similar to lipofuscin in that it stained positively with periodic acid-Schiff, oil red-0 and Victoria blue stains and revealed negative reactions to the immunohistochemical stains for S-100 protein and neuron specific enolase, but had similarity to melanin as shown by the positive reaction to Fontana-Masson stain and negative autofluorescence. The pigment of Dubin-Johnson syndrome showed the same histochemical and immunohistochemical characteristics as that of melanosis coli. The results indicate that the pigments of melanosis coli and Dubin-Johnson syndrome are identical and are variants of lipofuscin.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colonic Diseases / metabolism*
  • Histocytochemistry
  • Humans
  • Immunohistochemistry
  • Jaundice, Chronic Idiopathic / metabolism*
  • Male
  • Melanosis / metabolism*
  • Middle Aged
  • Pigments, Biological / metabolism*


  • Pigments, Biological