Human granulocytic Anaplasmosis, Japan

Emerg Infect Dis. 2013 Feb;19(2):289-92. doi: 10.3201/eid1902.120855.

Abstract

We retrospectively confirmed 2 cases of human Anaplasma phagocytophilum infection. Patient blood samples contained unique p44/msp2 for the pathogen, and antibodies bound to A. phagocytophilum antigens propagated in THP-1 rather than HL60 cells. Unless both cell lines are used for serodiagnosis of rickettsiosis-like infections, cases of human granulocytic anaplasmosis could go undetected.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anaplasma phagocytophilum / genetics*
  • Anaplasmosis / blood
  • Anaplasmosis / diagnosis*
  • Anaplasmosis / drug therapy
  • Anaplasmosis / immunology
  • Antibodies, Bacterial / blood
  • Bacterial Outer Membrane Proteins / immunology
  • DNA, Bacterial / blood
  • DNA, Bacterial / genetics
  • DNA, Bacterial / isolation & purification
  • Ehrlichiosis / blood
  • Ehrlichiosis / diagnosis*
  • Ehrlichiosis / drug therapy
  • Ehrlichiosis / immunology
  • Genes, Bacterial
  • HL-60 Cells
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Molecular Diagnostic Techniques
  • Molecular Typing
  • Phylogeny
  • RNA, Ribosomal, 16S / genetics
  • Retrospective Studies
  • Serologic Tests

Substances

  • Antibodies, Bacterial
  • Bacterial Outer Membrane Proteins
  • DNA, Bacterial
  • RNA, Ribosomal, 16S