Building biologics by chemical synthesis: practical preparation of di- and triantennary N-linked glycoconjugates

J Am Chem Soc. 2013 Mar 27;135(12):4700-3. doi: 10.1021/ja401385v. Epub 2013 Mar 19.

Abstract

A unified strategy for the syntheses of bi- and triantennary fully sialylated N-glycans is described. The synthesis capitalizes on a global glycosylation strategy that delivers the desired undeca- and tetradecasaccharide in excellent yields. Finally, conjugation of the glycan to PSMA oligopeptide is described.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antigens, Surface / chemistry*
  • Glutamate Carboxypeptidase II / chemical synthesis
  • Glutamate Carboxypeptidase II / chemistry*
  • Glycoconjugates / chemical synthesis*
  • Glycoconjugates / chemistry
  • Glycosylation
  • Oligopeptides / chemical synthesis
  • Oligopeptides / chemistry*
  • Polysaccharides / chemical synthesis
  • Polysaccharides / chemistry*

Substances

  • Antigens, Surface
  • Glycoconjugates
  • Oligopeptides
  • Polysaccharides
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II