Abstract
A unified strategy for the syntheses of bi- and triantennary fully sialylated N-glycans is described. The synthesis capitalizes on a global glycosylation strategy that delivers the desired undeca- and tetradecasaccharide in excellent yields. Finally, conjugation of the glycan to PSMA oligopeptide is described.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antigens, Surface / chemistry*
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Glutamate Carboxypeptidase II / chemical synthesis
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Glutamate Carboxypeptidase II / chemistry*
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Glycoconjugates / chemical synthesis*
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Glycoconjugates / chemistry
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Glycosylation
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Oligopeptides / chemical synthesis
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Oligopeptides / chemistry*
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Polysaccharides / chemical synthesis
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Polysaccharides / chemistry*
Substances
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Antigens, Surface
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Glycoconjugates
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Oligopeptides
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Polysaccharides
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FOLH1 protein, human
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Glutamate Carboxypeptidase II